Supandi Supandi, Supandi
Ethyl p-methoxycinnamate (EPMC) (1) is found as a major natural ester in the rhizome of Kaempferia galanga
(kencur) and has been known to have various pharmacological activities. The previous study has reported the
synthesis of N,N-bis-(2-hydroxyethyl)-p-methoxycinnamamide (2) by using microwave-assisted direct amidation
of EPMC (1) with diethanolamine. In this research, we attempt to synthesize of 2 by using a conventional direct
amidation of EPMC (1) with diethanolamine. The reaction was conducted without adding any coupling reagents
or catalyst. Structure of the synthetic product was determined by using analysis of GC-MS, IR, and 1H-NMR
spectroscopic data and then compared to the previously reported.
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