In major of its applying, CPOE has been shown to improve patient safety by reducing medication errors and subsequent adverse drug events (ADEs). Medication error such as elixir in writing, determination of dose and correct drug type use at patient with the certain health condition in health service can be depressed. But, and so do own the negative impact. One of them is the existence of time addition in entry of patient information by physician which is potential event for being an error(s) on prescribing activity. The goal was to describe the CPOE on prescribing, also as known as electronic prescribing, in academic health facility of GMC Health Center. This case study design, depth interview and observation was conducted in academic healthcare facility GMC Health Center. The subject was physician and farmacist as end-user of CPOE system on presribing. From interview guide and check list observation tools was obtained that CPOE in GMC Health Center have influenced by some principles from existing themes. Ease of use and usefullness perceptions had been change end-user’s mind about implementation of this systems.