Category: Repository

BACKGROUND: Corncob is one of crude drug which containing phenolic compounds that can be used as an active ingredient for sunscreen preparations. In this study, extracts of dried corn cob made into a gel formulation using SRC (Semi Refined Carrageenan) and glucomannan as a gelling agent.
AIM: This study aims to determine the optimal concentration of SRC (Semi Refined Carrageenan) and glucomannan to the physical stability of the gel.
METHODS: Gel made into four formulas with a ratio of 1: 4 and the concentration of each formula was 1%, 1.5%, 2%, 2.5%. Each formula was evaluated for 6 weeks of storage that includes organoleptic test, homogeneity, pH, viscosity, dispersive power, freeze-thaw test and centrifugation.
RESULTS: The results showed the fourth formula did not change the organoleptic test and homogeneity test. In the test separation of the freeze-thaw method, the fourth formula was stable, while in the centrifugation test formula 1 and 2 was been separation. pH and viscosity results obtained from statistics with a two-way ANOVA showed significant differences in each formula.
CONCLUSION: From the results of this study concluded that the formula 3 with a concentration of 2% was the optimal concentration as a gelling agent.

Citric acid is one of acid source that can increase dissolving time of effervescent
tablet. This study aims at determining the optimal concentration of citric acid as
acid source on dissolving time of effervescent tablet. Pericarp mangosteen
(Garcinia mangostana L) dry extracts macerated with water, and powder made by
spray drying process. Dry powder obtained was made into 5 formulas effervescent
tablets used different concentrations of citric acid, i.e. 20.0, 22.5, 25.0, 27.5, and
30.0%. The tablets were evaluated included organoleptic evaluation, weight
uniformity, size uniformity, hardness, friability, and dissolving times. The data in this
research were physical properties of granule and tablets. For physical granule
properties, i.e. flow time was fulfilling criteria, its flow time under 10 seconds for 100
g of granule. And also for angle of repose it was fulfill the criteria, it value was 25-
o
45 . The tablet data of dissolve time fulfilling criteria its value was under 1-5
minutes all. For pH value all the formula were safe to be consumed, the average
value was 4.347. By one-way ANOVA test dissolving time data there were
differences each other. It could be concluded that the optimum concentration of
citric acid as an acid source on dissolving time of the pericarp mangosteen
(Garcinia mangostana L.) dry extract effervescent tablets was formula 4 with citric
acid concentration of 27.5%.

Glutathione (GSH) is a broad antioxidant of the thiol-tripeptide group, highly hydrophilic, which has limitation for topical preparations. A lipophilic surfactant is an alternative method to enhance the glutathione partition. The purpose of this study was to determine the apparent partition coefficient (APC log) of glutathione; glutathione with additional surfactant at different HLB value of HLB 4.3; 5.5; 7; 11 and selected HLB was studied for penetration. The study was conducted by dissolving glutathione in water plus various HLB surfactants. Determination method of partition coefficient was done by shake flash method. The penetration test was conducted using the parameter of decreasing Matrix Metalloproteinase-1 expression on the balb-c male skin. The results can be used as a reference for topical glutathione formulations as these results are preformulation study.

Green tea leaf (Camellia sinensis L.) is a great plant containing polyphenol compounds
such as catechin and gallocatechin gallate that can be used as tyrosinase inhibitors. In
this study, the green tea leaf extract made into gel dosage form using sodium alginate as
a gelling agent. This research aimed to determine the effect of different sodium alginate
concentrations on the physical stability of gel extract green leaf and to know the effect of
gel formulation on tyrosinase inhibition. Gel made into 3 formulas with each
concentration of sodium alginate of 2; 2.5; 3%. The extraction of green tea leaves was
performed by reflux using 50% methanol solvent. The results showed that the three
formulas did not occur in phase separation, and had IC50 values of 34.80, 23.27, 20.69
μg/mL. The conclusion is gel dosage form with 3% sodium alginate gave the best
inhibition of tyrosinase with IC50 of 20.69 μg/mL.

Trees and shrubs of the genus Cordia are widely distributed in the warmer regions, including Indonesia. The aim of this study
was to evaluate the analgesic and anti-inflammatory properties of the ethanolic extract of plant leaves in Wistar albino rats.
The analgesic activity was evaluated using the hot plate method and acetic acid-induced writhing, and the anti-inflammatory
activity was determined using carrageenan-induced paw oedema. The results showed that the Cordia sebestena ethanol extract
(100, 200 and 400 mg/kg) exhibited significant analgesic effects in a dose-dependent manner in the two pain models tested. The
extract also exhibited significant anti-inflammatory effects in the carrageenan-induced inflammation test. The data obtained
support the traditional folklore therapeutic claim about its analgesic and anti-inflammatory properties. Nonetheless, further
scientific investigation is required to establish its analgesic and anti-inflammatory properties in other experimental models and
clinical settings.

Lactic Acid Bacteria (BAL) are often found naturally in food ingredients such as
vegetables and fruits. Cabbage fermentation is one of the best sources of Lactic Acid Bacteria
which contain antibacterial compounds such as bacteriocin, hydrogen peroxide, and organic
acids. This study purpose are to isolate BAL, screen the antibacterial activity, and identification
of molecular of selected isolates. This study was initiated with Lactic Acid Bacteria isolation from
cabbage fermentation, followed by screening for antibacterial activity by disc diffussion method
and identification of molecular isolates which having the highest antibacterial activity by PCR
method. After isolation, 6 isolates were obtained: K31, K32, K33, K34, K35 and K36. The result
of antibacterial activity test showed that K32 isolate had the highest activity against bacterium of
Bacillus cereus. Molecular identification with PCR method and sequencing of amplification
results showed that K32 isolates having 99% similarity level to lactobacillus buchneri JCM 115
strain. From the results of the study it can be concluded that cabbage fermentation contains
Lactic Acid Bacteria which have antibacterial activity against Bacillus cereus.

Berdasarkan data dari Riset Kesehatan Dasar (Riskesdas) 2013 kelompok remaja hingga dewasa muda
(15-24) memiliki gaya hidup tidak aktif (sedentary/kurang beraktivitas fisik) sebesar 52%. Kurangnya
aktivitas fisik dapat menyebabkan risiko kesehatan terutama timbulnya komplikasi penyakit tidak menular
seperti obesitas, diabetes, hipertensi dan gangguan jantung. Penelitian ini bertujuan untuk mengetahui
hubungan aktivitas fisik dan determinannya. Penelitian ini menggunakan metode kuantitatif dengan
desain studi potong lintang. Sejumlah 846 mahasiswa Fikes Uhamka berpartisipasi dalam penelitian ini.
Data dikumpulkan dengan mengisi sendiri kuesioner oleh mahasiswa. Analisis data menggunakan uji chi
square untuk mengetahui hubungan antara aktifitas fisik dengan determinannya dan regresi logistic untuk
mengetahui prediktor dari aktifitas fisik. Penelitian ini memberikan hasil bahwa rata-rata skor Metabolic
Equivalent (MET) adalah 1420,33 ± 2384,297. Responden yang memiliki aktivitas fisik yang rendah
sebesar 47,8%, aktivitas fisik sedang sebesar 39,6% dan aktivitas fisik tinggi hanya 12,6% responden. Ada
hubungan yang bermakna antara jenis kelamin, status pekerjaan, ketersediaan fasilitas olahraga, dukungan
dosen, dan persepsi terhadap olahraga terhadap aktivitas fisik. Aktivitas fisik aktif lebih banyak ditemui
pada responden kelamin laki-laki, mahasiswa yang sudah bekerja, ketersediaan sarana olahraga di rumah
atau lingkungan sekitar, adanya ajakan dosen untuk berolahraga dan adanya persepsi yang baik terhadap
olahraga. Hasil penelitian juga menunjukkan bahwa responden yang tidak bekerja, tidak terdapat fasilitas
olahraga di rumah, dan mempunyai persepsi yang kurang baik terhadap olahraga adalah prediktor untuk
memiliki aktivitas fisik pasif/ringan.

http://repository.uhamka.ac.id/879/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/879/1/B13.pdf Download Disini !

http://repository.uhamka.ac.id/881/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/881/1/B14.pdf Download Disini !

http://repository.uhamka.ac.id/882/ Prof. Dr. Atmazaki, Atmazaki http://repository.uhamka.ac.id/882/1/B15.pdf Download Disini !